准确性,可接受性和应用:便免疫化学测试,以早期检测基于结肠镜的监测中的晚期新生病
Molla M Wassie1, Maddison Dix2, Geraldine Laven-Law2
1Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5042, Australia. molla.wassie@flinders.edu.au.
便免疫化学测试 (FIT) 被接受用于高风险个体的结直肠癌监测. 间隔FIT有助于更早地检测晚期瘤,可能会个性化结肠镜检查计划.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 预防医学 预防医学
背景情况:
- 便免疫化学测试 (FIT) 是对结直肠癌 (CRC) 查的标准.
- 关于FIT在接受监视结肠镜检查的高风险个体中的实用性数据有限.
研究的目的:
- 评估间隔FIT的准确性,可接受性和有效性,以预测监测结肠镜间的晚期瘤 (晚期腺瘤或CRC).
- 评估FIT在个性化CRC监控策略中的作用.
主要方法:
- 在监测结肠镜检查之前,对614人进行了两样FIT (OC-传感器) 的诊断准确性评估.
- 对386人进行的调查评估了间隔FIT的可接受性.
- 对7331名提供间隔FIT的个人进行了回顾性分析,积极的结果引发了早期结肠镜检查.
主要成果:
- 在FIT中,CRC的敏感度为60.0%,晚期腺瘤的敏感度为27.1%.
- 89.1%的受访者认为间隔FIT可接受使用1-2年.
- 阳性FIT结果与更高的晚期瘤风险和诊断时间缩短有关.
结论:
- 间隔FIT得到了很好的接受,并促进了在高风险的CRC个体中早期检测晚期瘤.
- FIT对晚期瘤的预测价值支持其用于个性化监测结肠镜间隔的使用.
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