急性力量炼训练对抵抗炼训练个体的HERV-W表达和炎症生物标志物产生不同的影响
Lucas Vinicius Morais1, Samuel Nascimento Dos Santos1, Tabatah Hellen Gomes1
1Post-Graduation Program in Health Sciences, Santo Amaro University, São Paulo, Brazil.
抵抗运动可以提高人类内源性逆转录病毒W (HERV-W) 的调节,并调节炎症标志物,可能有助于骨肌肉的修复. 这项研究将训练有素的人与运动后的对照组进行了比较.
科学领域:
- 人类生理学 人类生理学
- 分子生物学分子生物学
- 运动科学运动科学
背景情况:
- 人体内源逆转录病毒 (HERVs) 占人类基因组的8%,并与肌肉修复等生理过程有关.
- 假设炎症调节HERV表达,可能会影响运动后的肌肉修复.
研究的目的:
- 为了研究急性力量训练后抵抗运动从业者的HERV表达和炎症概况.
- 为了确定在训练后的受过训练的个人和对照组之间,HERV表达和炎症标志物是否有差异.
主要方法:
- 研究了两个组:经常练习抵抗运动的练习者 (REG,n=27) 和未受过训练的对照组 (CG,n=20).
- 在运动前 (T0) 和运动后 (T1) 采集了血液样本,以分析HERV-K和HERV-W的表达,细胞因子水平和循环中的微粒.
主要成果:
- HERV-W的表达显著更高 (大约为0.5倍). 在REG中,与运动后的CG相比 (p<0.01).
- 在不同组或时间点之间,没有发现HERV-K表达的显著差异.
- 在两组运动后都观察到TNF-α和IL-10水平升高. 在REG (p=0.01) 中注意到TNF-α (T1) 和IL-10 (T0) 之间的正相关性.
- 在运动后,REG显示内皮微粒的减少 (p=0.04).
结论:
- 在训练过的人群中,抵抗运动会导致显著的HERV-W上调和炎症标志物调节.
- 这些变化表明HERV-W和炎症在运动后支持骨肌肉修复方面可能发挥作用.
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