在患有骨质疏松症的绝经后妇女中,德诺苏马布与阿伦德罗纳特的有效性比较
Jeffrey R Curtis1,2, Tarun Arora2, Ye Liu1
1University of Alabama at Birmingham, Division of Clinical Immunology and Rheumatology, Birmingham, AL, 35233, United States.
概括
与阿伦德罗纳酸相比,登诺苏马布在绝经后骨质疏松症 (PMO) 患者中显著降低了骨折风险. 较长时间使用德诺苏马布与更大的骨折风险降低相关,突出其在预防严重骨质疏松性骨折方面的有效性.
科学领域:
- 骨健康和骨质疏松症研究
- 对于骨疾病的药理干预措施
- 绝经后骨质疏松症的现实世界证据
背景情况:
- 临床试验表明,代诺苏马布比口服双酸盐更能增加骨矿物质密度.
- 缺乏评估骨折结果的头对头随机试验.
- 这项研究探讨了在现实环境中代诺苏马布与阿伦德罗纳特的比较有效性.
研究的目的:
- 评估德诺苏马布与阿伦德罗纳特在降低美国绝经后骨质疏松症 (PMO) 妇女骨折风险方面的比较有效性.
- 评估各种骨部位的骨折风险降低,包括部,非脊椎和脊椎骨折.
- 检查治疗时间对骨折风险降低的影响.
主要方法:
- 使用医疗保险服务费行政索赔数据的回顾性队列研究.
- 包括66岁以上的PMO妇女,开始使用德诺苏马布或阿伦德罗纳特 (2012-2018).
- 用治疗和审查权重的双倍强大的逆概率来估计骨折结果的风险比率.
主要成果:
- 与alendronate相比,德诺苏马布可以将严重骨质疏松性骨折 (MOP) 的风险降低39%.
- 在部 (36%),非脊椎 (NV; 43%),非部非脊椎 (NHNV; 50%) 和住院脊椎 (HV; 30%) 骨折中观察到显著的风险降低.
- 骨折风险的降低随着更长时间的登苏马布暴露而增加,在第5年,MOP骨折减少了31%.
结论:
- 与未经治疗的PMO患者中的alendronate相比,登诺苏马布在MOP,部,NV,NHNV和HV骨折中显示出临床显著的减少.
- 长期使用德诺苏马布与逐渐更大的骨折风险降低有关.
- 这些发现支持denosumab作为一种有效的治疗选择,以减少绝经后骨质疏松症中骨折风险.
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