尿中的分泌与儿科骨矿物质密度之间的关系:来自KNHANES V 2010-2011年的基于人口的研究
In Kyung Lee1,2, Yoo Mi Kim2,3, Han Hyuk Lim2,4
1Department of Pediatrics, Seoul St. Mary's Hospital, Seoul, South Korea.
概括
儿童和青少年高摄入量与较低的骨矿物质密度 (BMD) 有关. 减少可能对儿科骨健康至关重要.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 骨的新陈代谢 骨的新陈代谢
- 公共卫生 营养 公共卫生 营养
背景情况:
- 骨质疏松症是一个日益严重的全球健康问题.
- 和维生素D是已知的影响骨矿物质密度 (BMD) 的因素.
- (Na) 摄入量对儿科BMD的影响在很大程度上是未知的.
研究的目的:
- 调查韩国儿童和青少年尿液中的分泌与骨硬化之间的关联.
- 在儿科队列中探索摄入量水平和骨健康指标之间的关系.
主要方法:
- 利用来自韩国国家健康和营养检查调查V (2010-2011) 的2,018名参与者 (10-18岁) 的数据.
- 分析了尿中的与肌素 (Na/Cr) 比率作为分泌的标志物.
- 评估了腰椎,大腿和整个身体的BMDz分数.
主要成果:
- 男孩的每日摄入量明显高于女孩.
- 尿中较高的Na/Cr比率与摄入量呈正相关性.
- 较高的Na/Cr比率与多个骨部位的BMDz分数较低显著相关.
- 高分泌率 (第四四分位数) 与最低四分位数相比,增加了低BMDz分数 (LS,FN,WB) 的风险1.9-2.8倍,即使经过对混因子进行调整.
结论:
- 在韩国儿童和青少年的尿路分泌和BMD之间存在显著的负相关性.
- 研究结果强调需要公共卫生战略来管理年轻人群的摄入量.
- 建议进行进一步的纵向研究,以确认对儿科骨健康的长期影响.
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