方法验证研究Dipstick尿液分析作为查酸盐毒性查工具的方法验证研究
Jessicia S Schmitt1, Laura D Knight2
1From the University of Utah and ARUP Laboratories, Department of Pathology, Salt Lake City, UT.
概括
尿液测量棒可以在尸体解剖时快速查亚酸盐毒性. 玻璃体液和尿液为酸提供了最可靠的结果,有助于法医毒理学.
科学领域:
- 法医毒理学 法医毒理学
- 分析化学 分析化学
- 临床病理学 临床病理学
背景情况:
- 自2017年以来,故意摄入亚酸盐,特别是酸盐的发生率有所增加.
- 对于快速的酸盐/酸盐分析,商业实验室的选择有限.
- 对酸盐毒性进行解剖查对于准确确定死亡原因至关重要.
研究的目的:
- 为了研究尿液测量棒在尸检期间选潜在的酸盐毒性时的实用性.
- 为了评估不同生物标本 (血液,尿液,玻璃体,胃内含物) 的测量棒性能.
- 为了比较酸盐酸盐与酸暴露的测量棒有效性.
主要方法:
- 从已确认的酸盐/酸盐病例,酸病例和对照组的归档尸检样本进行了分析.
- 尿液测量棒用于检测血液,尿液,玻璃体液和胃内含物.
- 测试结果与病例状态和样本类型进行了比较.
主要成果:
- 尿液测量棒在所有酸/酸盐病例中为玻璃体液中的酸盐提供了快速,强烈的阳性结果.
- 在酸病例中,尿液 (2/4) 和胃含量 (1/4) 也观察到积极结果.
- 杆对酸毒性的可靠性有限,特别是通过吸入,在2个案例中没有积极的结果.
结论:
- 尿液测量棒是实验室测试的有价值,具有成本效益的辅助工具,用于尸体解剖时的酸盐毒性查.
- 玻璃体液和尿液是酸盐毒性病例中测量棒分析中最可靠的标本.
- 杆可能不适合检测酸的毒性,特别是通过吸入暴露.
相关概念视频
01:30Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
01:29Urine Studies I: Urinalysis
Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
01:24Serum Studies: Renal Function Tests
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
01:26Urine Studies II: Urine Culture and Sensitivity Test
A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...