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多发性硬化症中的心内膜介质厚度:一个CLSA研究

Ruth Ann Marrie¹, Ronak Patel², Stephen Allan Schaffer³

¹Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Can; Department of Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Can.

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概括

与对照人群相比,患有多发性硬化症 (MS) 的患者没有出现较高的亚临床动脉样硬化率. 心血管风险得分,而不是MS本身,在这个人群中预测动脉样硬化.

科学领域:

神经学神经学
心脏病学心脏病学
血管医学血管医学

背景情况:

多发性硬化症 (MS) 与动脉样硬化疾病的发病率增加有关,包括心脏病和中风.
Carotid intima 介质厚度 (CIMT) 作为动脉样硬化的一个关键代用标记.
这项研究调查了MS患者的CIMT与类风湿性关节炎 (RA) 患者和健康对照患者相比.

研究的目的:

为了比较患有多发性硬化症 (MS) 和没有MS的个体之间的鼻内膜介质厚度 (CIMT).
评估MS患者的亚临床动脉样硬化率.
为了确定MS是否是动脉样硬化的独立预测因素,超出已确定的心血管风险因素.

主要方法:

利用了加拿大长度老龄化研究 (CLSA) 的数据,排除了先前存在血管疾病的参与者.
在MS,RA和对照组的参与者中,通过带超声波测量CIMT.
采用后勤回归,对弗雷明汉风险评分 (FRS) 和其他共同变量进行调整,以分析队列成员和动脉样硬化之间的关联 (CIMT ≥75百分位数).

主要成果:

在MS,RA和对照组之间没有发现平均CIMT的显著差异.
根据CIMT,队列成员 (MS,RA,对照) 与亚临床动脉样硬化不相关.
较高的弗雷明汉风险评分 (FRS) 与动脉样硬化几率的增加显著相关.

结论:

平均CIMT在患有MS,RA或两种疾病的个体之间没有差异.
在MS患者的亚临床动脉样硬化并没有超过基于FRS的预测.
需要进一步的研究,以阐明MS中心血管疾病和中风率增加背后的机制.

关键词:

动脉样硬化是一种动脉样硬化.这就是CLSA CLSA.动脉内膜介质的厚度动脉内膜介质的厚度多发性硬化症是多发性硬化症.类风湿性关节炎类风湿性关节炎类风湿性关节炎

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