绝经后的激素治疗和双胞胎的认知能力
Laura L Johansen1, Kaare Christensen1, Jesper Hallas2
1Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark; The Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark; Danish Aging Research Center, Unit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.
概括
绝经后使用激素治疗可能会对老年女性的认知功能产生不同的影响. 研究结果表明,2002年以后,这种关联发生了转变,可能是由于激素治疗用户配置文件的变化.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 老年学是一门学科.
背景情况:
- 轻度认知障碍可能源于长期的病理生理学变化.
- 假设雌激素在预防认知能力下降方面的潜在作用.
- 妇女健康倡议 (WHI) 研究在2002年显著影响了激素治疗 (HT) 使用模式.
研究的目的:
- 研究绝经后激素治疗与丹麦女双胞胎认知功能之间的关联.
- 分析在2002年WHI研究发表之前和之后这种关联的变化.
主要方法:
- 对4510名50岁及以上的双胞胎进行认知评估.
- 激素治疗使用数据来自丹麦卫生登记处.
- 分析包括横截面,内对和纵向方法,并调整了混因素.
主要成果:
- 70岁以上的系统性HT使用者比非使用者表现出较低的认知功能,特别是在2002年之前.
- 使用全身HT的年轻双胞胎 (50-69岁) 在2002年后表现出较低的认知功能.
- 50-69岁的女性在2002年后转向局部HT或停止使用后,表现出更好的认知表现.
结论:
- 激素治疗和认知之间的关联似乎在2002年后发生了变化.
- 这表明,2002年WHI发现后,激素治疗用户的特征发生了变化.
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