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在中国人群中,FOXP3基因与缺血性中风的易感性有关

Youpei Wang¹, Tiru Shan¹, Peipei Mao¹

¹Department of Geriatric Medicine, Qingdao Chengyang People's Hospital, Qingdao 266109, China.

Clinical neurology and neurosurgery

|May 16, 2024

概括

叉头盒P3 (FOXP3) 基因的遗传变异,特别是rss3761548和rss2232365的多态变异,与中国汉族人群中缺血性中风 (IS) 的风险和严重程度增加有关. 这些发现突出了FOXP3基因多态性作为IS的潜在生物标志物.

科学领域:

遗传学遗传学是一个
免疫学免疫学免疫学
神经学神经学

背景情况:

免疫炎症反应是缺血性中风 (IS) 病理生理学的组成部分.
叉头盒P3 (FOXP3) 是免疫细胞功能的关键调节者.
FOXP3基因多态可能会影响IS易感性.

研究的目的:

调查FOXP3基因多态 (rs3761548和rs2232365) 与IS易感性之间的关联.
评估这些多形态和IS严重程度在汉族人口中之间的关系.

主要方法:

使用聚合酶链反应和桑格测序,对FOXP3基因多态 (rs3761548和rs2232365) 的基因定型.
统计分析以评估与IS易感性和严重性的关联,并根据临床因素进行调整.

主要成果:

rs3761548多态 (GT和GT+TT基因型) 与IS易感性升高显著相关 (调整后的OR从1.720到1.736不等).
衰退模型中的rs2232365多态性也与IS易感性增加有关 (调整后OR=1.876).
两种rs3761548 (主导模型,调整OR=2.601) 和rs2232365 (衰退模型,调整OR=3.545) 多态都与IS严重程度相关.

结论:

已确定FOXP3基因多态 rs3761548和rs2232365是缺血性中风易感性和严重性的危险因素.
这些遗传变异可能作为预测IS风险和结果的潜在生物标志物.

关键词:

这是FOXP3P3的.缺血性中风是因为缺血性中风.多态形态的多态化

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