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Updated: Jun 6, 2026

In vitro Methylation Assay to Study Protein Arginine Methylation
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发现了蛋白质氨酸甲基转移酶6 (PRMT6) 的第一类降解剂

Hongling Yang1, Qiangsheng Zhang1, Shuyan Zhou1

  • 1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, 17#3rd Section, Ren Min South Road, Chengdu 610041, China.

Bioorganic chemistry
|May 16, 2024
PubMed
概括

研究人员开发了SKLB-0124,一种针对PRMT6 (蛋白质氨酸甲基转移酶6) 的新型蛋白质降解剂. 这种新的候选药物有效地抑制癌细胞增殖并诱导细胞亡,显示出癌症治疗的前景.

关键词:
抗癌剂是一种抗癌剂.希斯甲基化 希斯甲基化疏水标记方法是一种疏水标记方法.在PRMT6中使用.蛋白质降解剂可以降解蛋白质.

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