在听觉图像中语言网络的低活化有助于精神分裂症患者的幻觉
Luca Besso1, Sara Larivière2, Meighen Roes3
1BC Mental Health and Addictions Research Institute, Provincial Health Services Authority, Vancouver, BC, Canada; Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.
经历听觉语言幻觉的精神分裂症患者在听觉图像任务中显示出改变的大脑活动. 这表明受损的内部语言处理有助于幻觉的发展.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 听觉语言幻觉 (AVH) 是一种常见的精神分裂症症状.
- 计量压力评估依赖于听觉图像.
- 之前的研究表明,幻觉患者的布罗卡和韦尔尼克区域的连接性减少.
研究的目的:
- 在听觉成像过程中调查精神分裂症患者与AVH的全脑网络差异.
- 使用功能磁共振成像 (fMRI) 分析功能性大脑网络反应.
主要方法:
- 使用前一项研究的fMRI数据进行全脑网络分析.
- 提取和分析三个功能性大脑网络.
- 在听觉成像任务期间,幻觉患者和对照者之间的血液氧气水平依赖 (BOLD) 反应的比较.
主要成果:
- 语言网络 (LN) 在听觉图像期间幻觉患者中表现出更早,更浅的BOLD反应.
- 减少LN中的激活是特定于听觉图像条件的.
- 这些发现并不局限于最初研究的兴趣区域 (ROI).
结论:
- 在内部听觉图像中语言网络的低活化可能会增加经历AVHs的可能性.
- 内部和外部语言处理之间的不平衡,以内部听觉图像网络的低活性为特征,与幻觉的生物学基础有关.
- 这项研究提高了对精神分裂症幻觉的神经生物学基础的理解.
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