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相关概念视频

From DNA to Protein03:06

From DNA to Protein

18.3K
The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...
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The Central Dogma01:20

The Central Dogma

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The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
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Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

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The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
7.1K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

7.9K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
7.9K
Exon Recombination02:32

Exon Recombination

3.6K
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon...
3.6K
Genome Copying Errors02:46

Genome Copying Errors

4.2K
DNA replication is a well-evolved process that copies millions of base pairs with high fidelity during each cell division. Occasionally a wrong base or a long stretch of wrong bases may get added to the daughter strands. If the errors are left unchecked, cells might accumulate several mutations that might endanger their  survival. Therefore, the copying errors are checked and repaired at three levels.
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相关实验视频

Updated: Jun 26, 2025

A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli
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A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli

Published on: December 9, 2017

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强大的遗传密码可以增强蛋白质的进化能力.

Hana Rozhoňová1,2, Carlos Martí-Gómez3, David M McCandlish3

  • 1Institute of Integrative Biology, ETH Zürich, Zürich, Switzerland.

PLoS biology
|May 16, 2024
PubMed
概括
此摘要是机器生成的。

标准的遗传密码 标准的遗传密码

更多相关视频

Identifying Amino Acid Overproducers Using Rare-Codon-Rich Markers
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Identifying Amino Acid Overproducers Using Rare-Codon-Rich Markers

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Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability
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Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability

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相关实验视频

Last Updated: Jun 26, 2025

A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli
11:08

A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli

Published on: December 9, 2017

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Identifying Amino Acid Overproducers Using Rare-Codon-Rich Markers
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Identifying Amino Acid Overproducers Using Rare-Codon-Rich Markers

Published on: June 24, 2019

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Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability
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Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability

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科学领域:

  • 分子生物学分子生物学
  • 进化生物学 进化生物学
  • 合成生物学 合成生物学

背景情况:

  • 标准的遗传密码决定了蛋白质的翻译,并影响了蛋白质的可变性.
  • 代码对突变的稳定性是关键特征,但它对可进化的影响仍在争论中.

研究的目的:

  • 调查遗传密码重新连接如何影响蛋白质的可进化性.
  • 为了确定强大的遗传密码是否增强或阻碍适应性进化.

主要方法:

  • 使用大规模并行序列到函数测试分析经验适应性景观.
  • 构建和检查数十万个重新连接的遗传密码,包括密码压缩方案.

主要成果:

  • 强大的遗传密码通常通过创造更平稳的适应性景观来提高蛋白质的进化能力.
  • 标准的遗传密码并不例外;许多替代代码可以产生更光滑的景观.
  • 重制代码显著改变了高适应性基因型网络的拓.

结论:

  • 替代遗传代码可以被设计为增强或减少蛋白质的可进化性.
  • 这些发现为有针对性的蛋白质进化和合成生物的生物控制提供了设计原则.