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Updated: Jun 26, 2025

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
11:44

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3

Published on: January 24, 2016

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抑制R循环介导的STING型I干扰素通路激活抗瘤免疫

Matthew B Maxwell1, Marianne S Hom-Tedla2, Jawoon Yi3

  • 1Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Biological Sciences Graduate Program, University of California, San Diego, La Jolla, CA 92092, USA; NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

Cell
|May 16, 2024
PubMed
概括

通过上调干扰素特征,ARID1A突变增强了抗瘤免疫力和对免疫检查点阻塞 (ICB) 的反应. 这涉及R环,细胞核DNA和STING信号,揭示了ICB有效性的关键机制.

关键词:
其他:在R循环中一个SWI/SNF复合体抗瘤免疫力癌症免疫疗法细胞质DNA一种类型的IFN

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