利可卡尔康D通过调节脂质生成和自细胞来改善肝细胞中的脂质代谢
Chian-Jiun Liou1, Shu-Ju Wu2, Hui-Chi Yang3
1Department of Nursing, Division of Basic Medical Sciences, Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, No.261, Wenhua 1st Rd., Taoyuan City, 33303, Taiwan; Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou, Taoyuan City, 33303, Taiwan.
European journal of pharmacology
|May 16, 2024
概括
利可卡尔康D是一种来自Glycyrrhiza inflata的化合物,有效地减少了代谢功能障碍相关的脂肪肝炎 (MASH) 的肝脏脂肪积累和炎症. 它通过调节脂质代谢和促进自作用来起作用,为脂肪肝疾病提供了潜在的治疗策略.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 分子生物学分子生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 代谢功能障碍相关的脂肪肝疾病 (MASH) 的特征是过度的脂质积累,炎症和肝脏纤维化.
- 利科卡尔康D是来自Glycyrrhiza inflata的一种卡尔康,具有抗瘤和抗炎性质.
- 在MASH中调节脂质新陈代谢的利科哈尔科恩D的作用仍需要阐明.
研究的目的:
- 为了研究甲D对脂肪肝细胞和MASH动物模型中的脂质积累的影响.
- 为了探索利科哈尔科尼D调节脂质代谢和自的分子机制.
主要方法:
- 已建立的脂肪肝细胞模型使用FL83B肝细胞与油酸处理.
- 在C57BL/6小鼠中诱导了MASH,使用的是甲素/胆缺乏的饮食.
- 用利科哈尔科尼D处理的细胞和动物,并评估脂质代谢,炎症,纤维化和自标志物.
主要成果:
- 利可卡尔康D通过抑制SREBP-1c和FAS显著降低了肝细胞中的脂质积累,同时通过ATGL和CPT1.1增强了脂解和脂肪酸氧化.
- 它调节了SIRT-1,AMPK和ACC酸化,影响了脂肪酸合成.
- 在MASH小鼠中,利可卡尔康D通过增加自菌体-溶解体融合和减少肝脂真空,纤维化和炎症来促进自.
结论:
- 利科哈尔科恩D显示出对MASH的显著治疗潜力.
- 它通过减少肝脏脂质积累,抑制炎症和增强自来改善MASH.
- 利科哈尔科恩D代表了治疗代谢功能障碍相关的脂肪肝炎的有前途的药物.
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