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生物仿真牙重矿化使用蛋衍生的纳米基亚帕提特,含有或不含有碳甲基 - 一项体外研究

Balasubramanian Saravana Karthikeyan¹, Sekar Mahalaxmi¹

¹Department of Conservative Dentistry and Endodontics, SRM Dental College, Bharathi Salai, SRM Institute of Science and Technology, Chennai 600 089, India.

International journal of biological macromolecules

|May 16, 2024

概括

蛋衍生的纳米酸 (EnHA) 和碳甲基 (CMC) 有效地重矿化牙病变. EnHA-CMC组合显示出卓越的结果,促进了快速生物矿物化和增强牙微硬度.

科学领域:

生物材料科学生物材料科学
在牙科的纳米技术.
牙科材料研究牙科材料研究

背景情况:

牙损涉及去矿化,需要有效的重矿化策略.
纳米材料为增强牙组织的仿生修复提供了潜力.
蛋衍生的纳米酸 (EnHA) 和碳氧甲基 (CMC) 是具有牙重矿化潜力的生物相容材料.

研究的目的:

评估EnHA和CMC对人工诱导的牙病变的协同重矿效应.
评估EnHA-CMC处理对牙微硬度,表面地形和化学成分的影响.
为了确定EnHA和CMC的细胞相容性,用于潜在的治疗应用.

主要方法:

使用FTIR,XRD,HRSEM-EDX,TEM,DLS和TGA/DTA对EnHA和CMC进行合成和表征.
用人工唾液,EnHA,CMC或EnHA-CMC对64个预先脱矿牙样本进行处理,然后进行7天的pH循环.
使用HRSEM-EDX,维克斯微硬度测试和微拉曼光谱测试评估重矿化;通过hDPSCs的MTT测试评估细胞毒性.

主要成果:

与其他组相比,EnHA-CMC治疗导致牙管完全封闭,并且显著提高了微硬度 (p < 0.05).
证实EnHA和CMC材料对人类牙髓干细胞 (hDPSCs) 无细胞毒性.
分子分析显示,用CMC和EnHA-CMC处理的牙中增强了原稳定性,表明结构完整性得到改善.

结论:

EnHA和CMC的组合表现出协同作用,显著增强牙病变的重矿化.
EnHA-CMC显示出作为一种新型治疗剂的潜力,用于有效的生物矿物化和牙损伤的治疗.
该研究证实了EnHA-CMC在牙科再生应用中的生物相容性和仿生潜力.

关键词:

人工脏病的人工脏病生物模拟性矿化碳氧甲基基托桑是一种碳氧甲基基托桑.牙上的牙.蛋粉是什么意思纳米-氧亚帕提特是一种纳米-氧亚帕提特.

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