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准备Eudragit S100-pullulan/hydroxypropyl-β-cyclodextrin复合物-Eudragit S100多层纳米纤维薄膜用于输送白醇的结肠

Congyi Nie¹, Qian Liang¹, Qunyu Gao¹

¹Carbohydrate Laboratory, School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, PR China; Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, Guangzhou 510640, PR China.

International journal of biological macromolecules

|May 16, 2024

概括

propyl-β-cyclodextrin (HPβCD) 和多层纳米纤维增强了向结肠输送的白醇 (RSV). 这种新的系统改善了RSV的保存和抗氧化活性,用于有针对性的结肠释放.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
制药科学制药科学

背景情况:

电纳米纤维具有封装不稳定的化合物的潜力.
一些纳米纤维的快速溶解限制了它们在药物输送中的应用.
xypropyl-β-cyclodextrin (HPβCD) 可以形成包含复合物以稳定化合物.

研究的目的:

使用HPβCD和多层纳米纤维开发一种针对结肠的白醇 (RSV) 输送系统.
为了提高RSV在结肠中的稳定性和受控释放.
研究多层结构和HPβCD在RSV传递中的作用.

主要方法:

形成一个白醇/HPβCD纳入复合体 (HPIC).
将HPIC纳入pullulan纳米纤维中的方法.
用Eudragit S100 (ES100) 和pullulan/HPIC纳米纤维制造一个多层结构.
评估热稳定性,水接触阻力和RSV释放配置文件.

主要成果:

ES100-pullulan/HPIC-ES100多层薄膜表现出增强的热稳定性和耐水性.
大约78.58%的RSV被释放到结肠中,这表明结肠向性很好.
与对照组相比,多层膜显示出更高的封装效率和RSV的抗氧化活性增加.

结论:

多层ES100-pullulan/HPIC-ES100纳米纤维提供了一个有前途的策略,用于结肠向输送RSV.
HPβCD纳入复合体和多层结构显著改善了RSV的保存和释放特性.
这种方法为设计结肠药物输送系统提供了一种安全有效的方法.

关键词:

针对结肠的多层纳米纤维薄膜.含有基烯-β-环氧德克斯的综合体.普鲁伦的多糖是普鲁伦的多糖.

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