精神分裂症频谱和情绪障碍中的认知和肠道微生物群:系统性审查
S Frileux1, M Boltri2, J Doré3
1Service Hospitalo-Universitaire de Psychiatrie d'Adultes et d'Addictologie, Centre Hospitalier de Versailles, 177, rue de Versailles, Le Chesnay-Rocquencourt 78157, France; Université Paris-Saclay, Université Versailles Saint-Quentin-En-Yvelines, DisAP-DevPsy-CESP, INSERM UMR1018, Villejuif 94807, France.
Neuroscience and biobehavioral reviews
|May 16, 2024
概括
肠道失调与精神分裂症和情绪障碍中的认知障碍有关. 特定的细菌可能会影响认知表现,像益生菌这样的干预措施对增强表现有希望.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 微生物学 微生物学
背景情况:
- 在精神分裂症频谱和情绪障碍中,认知障碍很普遍.
- 新兴研究表明,肠道微生物群与认知功能之间存在联系.
研究的目的:
- 系统地审查肠道微生物群和精神分裂症频谱和情绪障碍中的认知之间的关系.
- 为了确定特定的微生物种群和干预与这些条件的认知表现相关的干预.
主要方法:
- 来自主要数据库 (如PubMed,Scopus) 的研究的系统审查.
- 包括标准侧重于肠道微生物群,通过神经心理评估认知功能,以及特定的精神疾病.
- 分析了十项已识别的研究.
主要成果:
- 肠道失调症和认知障碍之间存在显著的联系.
- 特定的种类如Haemophilus, Bacteroides和Alistipes与更好的认知有关.
- 坎迪达阿尔比坎斯 (Candida albicans),毒素菌 (Toxoplasma gondii),细菌菌 (Streptococcus) 和菌菌 (Deinococcus) 都与较差的认知表现有关. 这些疾病与较差的认知表现有关.
- 益生菌和益生菌干预证明了认知能力的提高,特别是在执行职能方面.
结论:
- 肠道微生物群在精神疾病中的认知功能中起着至关重要的作用.
- 确定特定的微生物点和干预措施可能会导致精确的精神病学方法.
- 进一步研究底层机制是有必要的.
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