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Updated: Jun 26, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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在神经精神病学表型中,孕产妇免疫激活和产后免疫应激之间的相互作用

Pengsheng You1, Jiaping Sui1, Zhongman Jin1

  • 1State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China; Neuroscience Center, Chinese Academy of Medical Sciences, Beijing 100005, China.

Behavioural brain research
|May 16, 2024
PubMed
概括

在小鼠中,孕产妇免疫激活 (MIA) 会导致终身行为问题和免疫反应的改变. 不同年龄段的产后感染会影响这些缺陷,为发展性精神疾病揭示了关键的干预窗口.

关键词:
行为表现型 行为表现型孕产妇免疫激活 (MIA) 的原因神经病理学现象型的神经病理学现象型产后的免疫压力是产后的免疫压力.

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Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
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Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
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