动脉硬和发生的玻璃眼:一个基于人口的大型队列研究
Angela L Beros1, John D Sluyter1, Alun D Hughes2
1School of Population Health (A.L.B., J.D.S., R.K.R.S.), University of Auckland, Auckland, New Zealand.
American journal of ophthalmology
|May 16, 2024
概括
通过大动脉脉冲波速度 (PWV) 测量的动脉硬与患青光眼的风险更高有关. 这种简单的测量可以帮助识别需要更密切监测青光眼的人.
科学领域:
- 眼科医生 眼科 眼科
- 心血管医学 心血管医学
- 流行病学 流行病学
背景情况:
- 动脉硬是心血管健康的指标.
- 玻璃眼是导致不可逆转失明的主要原因.
- 早期识别眼风险因素对于及时干预至关重要.
研究的目的:
- 为了确定使用振荡计方法评估的动脉硬是否与玻璃眼的发病率有关.
- 评估动脉硬性的特定测量,包括大动脉脉冲波速 (aPWV),估计的动脉-大腿骨PWV (ePWV) 和大动脉脉压 (aPP).
主要方法:
- 一个前性,基于人口的队列研究,涉及4713名50-84岁的参与者,没有已知的玻璃眼.
- 使用aPWV,ePWV和aPP进行了动脉硬度测量.
- 经过国家卫生登记,在平均后续10年半的时间里,通过国家卫生登记识别了发生眼的病例.
- 考克斯比例危险回归被用来分析动脉硬性和玻璃眼风险之间的关联.
主要成果:
- 增加的动脉硬度,特别是更高的aPWV和ePWV,与患青光眼的更高风险显著相关.
- 在aPWV和ePWV的最高四分位数中的参与者具有明显增加发生眼的风险.
- 虽然aPP显示出趋势,但只有aPWV和ePWV显示出与玻璃眼发病率的统计学意义上的关联.
结论:
- 动脉硬度可以通过振荡计仪器轻松测量,作为发生性绿眼病的预测标记.
- 这些发现表明,对动脉硬度的评估可以纳入临床实践,以对玻璃眼风险分层进行分层.
- 这项研究为针对动脉硬的治疗干预措施开辟了潜在的途径,以预防或治疗眼.
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