败血症损害了缺血性中风后的神经恢复,并与性别差异有关
Larissa Silva Joaquim1, Beatriz Steiner2, Brenno Farias2
1Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit, University of South Santa Catarina, Tubarao, SC, Brazil; Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina, Criciuma, SC, Brazil.
Life sciences
|May 16, 2024
概括
缺血性中风后的败血症早期影响雄性大鼠,导致神经炎症和氧化应激. 女性在晚些时候表现出更糟糕的结果,在败血症后长期记忆力受损.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 病理生理学 病理生理学
背景情况:
- 感染是中风后的一个已知的并发症,结果可能在性别之间有所不同.
- 了解缺血性中风后对败血症的反应的性别差异对于开发向疗法至关重要.
研究的目的:
- 为了研究毒症对缺血性中风后大脑的影响,特别关注性别差异.
- 分析神经炎症,氧化应激和中脑动脉封闭 (MCAO) 后的雄性和雌性大鼠的线粒体活动,其次是败血症.
主要方法:
- 雄性和雌性Wistar大鼠接受了MCAO,然后七天后通过结和穿孔 (CLP) 诱导败血症.
- 在前额叶皮层和海马体中评估了心脏病发作的大小,神经炎症标记物 (细胞因子,质激活),氧化应激标记物 (MPO,酸盐/酸盐,蛋白质氧化) 和线粒体活性 (catalase).
- 在MCAO后和CLP后的不同时间点评估了生存率,神经学分数和长期记忆.
主要成果:
- 败血症 (CLP) 降低了MCAO后雌性大鼠的生存率和恶化了神经功能损害.
- 雄性大鼠在败血症后早期在海马体中经历了质激活和促炎细胞因子 (TNF-α,IL-1β) 的增加.
- 两种性别都显示IL-6和髓氧化酶 (MPO) 的增加,但男性在海马体中表现出更高的MPO和酸盐/酸盐,以及蛋白质氧化增加.
- 患有MCAO+CLP的女性在前额叶皮质中表现出更高的线粒体复合体活性,并发展出长期记忆障碍.
结论:
- 在大鼠中缺血性中风后的早期败血症呈现出明显的性别特异性病理生理变化.
- 男性表现出更明显的早期神经炎症和氧化应激反应,而女性更容易出现长期的神经缺陷,包括记忆障碍.
相关概念视频
01:15Ischemic Stroke l: Introduction
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
01:15Ischemic Stroke ll: Pathophysiology
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
01:29Hemorrhagic Stroke ll: Pathophysiology
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...