早期哺乳期的全身炎症及其与牛的氧化和代谢状态,生产和生殖性能以及活动的关系
M Q Zhang1, S Heirbaut1, X P Jing2
1Laboratory for Animal Nutrition and Animal Product Quality, Department of Animal Sciences and Aquatic Ecology, Faculty of Bioscience Engineering, Ghent University, 9000 Gent, Belgium.
Journal of dairy science
|May 16, 2024
概括
临床上健康的奶牛在过渡期具有较低的炎症反应,表现出更好的代谢健康和生产力. 这表明,即使是亚临床炎症也会影响奶牛的健康和表现.
科学领域:
- 兽医免疫学 兽医免疫学
- 乳牛的繁殖 乳牛的繁殖
- 动物代谢 动物代谢
背景情况:
- 失调的炎症反应与过渡期奶牛的疾病有关.
- 在此期间,表征健康的牛有增强的炎症是不完整的.
研究的目的:
- 评估过渡期奶牛炎症反应升高与代谢/氧化状态之间的关系.
- 评估炎症状态对临床健康奶牛过渡期结果的影响.
主要方法:
- 在多个时间点 (例如: -7, 3, 6, 9, 21 DIM) 从99只过渡期奶牛中采集了血液样本.
- 分析了代谢 (葡萄糖,NEFA,IGF-1),氧化 (GPx,MDA) 和急性阶段蛋白质 (APP:Hp,SAA,A:G) 的参数.
- 基于APP的K-medoids集群分类奶牛成急性阶段反应 (APR) 和非APR组.
主要成果:
- 与APR组相比,非APR组的SAA和Hp较低,A:G较高.
- 没有APR的奶牛比患病的奶牛表现出更高的IGF-1和更低的NEFA度.
- 患病的奶牛的干物摄入量和牛奶产量下降;APR奶牛的活动水平较低.
结论:
- 产后炎症状况较低的奶牛表现出更好的代谢健康,生产力和活动.
- 过渡期奶牛的亚临床炎症虽然具有有限的有害影响,但与较差的结果有关.
- 监测炎症标志物可以帮助识别有代谢和生产挑战风险的奶牛.
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