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意大利伦巴第地区鼻癌发病率,2008-20

D Consonni¹, G Stoppa², A Binazzi³

¹Occupational Health Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.

Occupational medicine (Oxford, England)

|May 16, 2024

概括

对木材和皮革灰尘的职业暴露在患有鼻癌 (SNC) 的男性中很常见. 这些暴露,特别是皮革灰尘,在意大利西部的地理位置上聚集在一起,突出了工作场所的风险.

科学领域:

流行病学流行病学
职业健康职业健康职业健康
在瘤学瘤学.

背景情况:

皮质鼻癌 (SNC) 是一种罕见的瘤,与木尘,皮革尘,,和甲等职业致癌物质有关.
2008年,意大利建立了一个国家SNC注册表,以追踪这些罕见的癌症.

研究的目的:

分析时间趋势,职业暴露和意大利伦巴第省SNC的地理分布,从2008年到2020年.
确定该地区与SNC相关的特定职业致癌物.

主要方法:

使用了伦巴第SNC注册表的数据,包括采访,使用职业历史标准化问卷.
在市级计算的原始和年龄标准化发病率 (ASR) 和标准化发病率 (SIR).
采用贝叶斯模型生成平滑的SIR地图用于地理分析.

主要成果:

记录了827例上皮SNC病例 (553名男性,274名女性),发生率没有显著的时间趋势.
鉴定了高水平的职业致癌物暴露,特别是男性 (45%暴露).
木材和皮革灰尘是主要的暴露;75%的男性腺癌病例涉及木材/皮革灰尘的暴露. 在西部地区发现皮革粉尘暴露的SIR值升高.

结论:

显著比例的鼻癌病例,特别是男性,与职业暴露有关,特别是木材和皮革灰尘.
伦巴第西部皮革粉尘暴露的地理聚类表明局部工业风险,特别是在鞋业.

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