关键脊柱脱线化病变的MR成像特征与渐进的运动障碍相关
B Mark Keegan1, Steven A Messina2, Dennis Hanson3
1From the Department of Neurology (B.M.K., E.S., S.N., B.B., R.A., J.M., O.K., B.G.W., E.P.F.), Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, Minnesota keegan.bmark@mayo.edu.
AJNR. American journal of neuroradiology
|May 16, 2024
概括
多发性硬化症 (MS) 中的关键性脱髓化病变与渐进的运动软弱有关. 脊髓MRI功能,如焦点缩和横向位置有助于识别这些关键病变.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 神经免疫学 神经免疫学
背景情况:
- 渐进性多发性硬化症 (MS) 往往表现为骨髓病症状,其特征是不对称的运动软弱.
- 焦点脱髓脊髓损伤解剖学上与渐进的运动障碍有关,假设可以解释这些症状.
- 这种假设得到了渐进性孤独性硬化症,渐进性稀疏硬化性多发性硬化症和渐进性单侧半性多发性硬化症 (PUHMS) 的观察结果的支持.
研究的目的:
- 描述脊髓磁共振成像 (MRI) 特定特征的关键脱髓化病变.
- 将这些关键病变与进展性多发性硬化症患者的非关键性脱髓化病变进行比较.
- 为了确定与MS中渐进的运动损伤相关的MRI特征.
主要方法:
- 进行了一项回顾性,观察性MRI研究.
- 91名患者的脊髓MRI扫描 (宫和胸部) 被神经放射学家审查.
- 关于渐进性运动损伤的临床数据由多发性硬化症子专家独立证实与MRI发现相关.
主要成果:
- 在91名患者中,评估了91个关键和98个非关键脊髓病变.
- 关键性病变与中度至严重的焦点脊髓缩 (45%vs0%),侧柱轴位置 (OR,10.43) 和较大的病变大小有显著联系.
- 多重回归分析确定了焦点缩和侧轴位置作为关键脱髓化病变最强的预测因素.
结论:
- 焦点,病变相关的缩,侧柱轴位置和较大的病变大小是MS中关键脱髓化病变的关键MRI特征.
- 在脊髓MRI上识别这些特征对于了解渐进性运动障碍的发展至关重要.
- 在临床评估中,应积极寻找具有运动缺陷的多发性硬化患者中存在关键脱髓化病变的存在.
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