在接受抗血栓治疗时,患有非的上胃肠道出血的患者的改善结果:倾向性得分匹配分析
Fatih Acehan1, Buket Karsavuranoğlu1, Meryem Aslan1
1Department of Internal Medicine, Ankara City Hospital, Ankara, 06800, Turkey.
概括
在上部胃肠道出血 (UGIB) 之前使用抗血栓剂显著降低了死亡率. 服用抗血栓剂的患者在住院,30天和90天的死亡率较低,这表明抗血栓剂具有保护作用.
科学领域:
- 胃肠病学 胃肠病学
- 心脏病学 心脏病学
- 临床医学 临床医学
背景情况:
- 非的上部胃肠道出血 (UGIB) 带来了重大的临床挑战.
- 抗血栓治疗在UGIB患者中的作用需要澄清.
研究的目的:
- 调查先前存在的抗血栓使用对非水性UGIB患者的临床结果的影响.
- 为了确定抗血栓使用是否与这种患者群体的死亡率有关.
主要方法:
- 在2019年2月至2020年9月期间,对患有非变节性UGIB的患者进行了队列研究.
- 倾向性得分匹配 (PSM) 和多变量回归分析用于比较抗血栓使用者和非使用者.
- 评估了临床结果,包括死亡率.
主要成果:
- 在PSM队列 (157对) 中,抗血栓使用者30天 (4.5%对14.0%) 和90天 (8.9%对18.5%) 的死亡率显著降低.
- 整个队列的多变量分析显示,抗血栓使用与减少住院 (aOR:0.437),30天 (aOR:0.261) 和90天 (aOR:0.386) 的死亡率有关.
- 抗血栓使用者经历了更长的住院时间和更高的ICU入院率,但证明了更好的生存率.
结论:
- 在非水性UGIB呈现之前使用抗血栓剂是一种独立的保护因素,可以防止因任何原因的死亡率.
- 这些发现表明,在某些患有UGIB的患者中,继续抗血栓治疗可能有好处.
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