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保存的调节开关用于鸟类从新生羽毛过渡到幼羽毛的过渡
Chih-Kuan Chen1,2,3,4, Yao-Ming Chang5, Ting-Xin Jiang1
1Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Nature communications
|May 16, 2024
概括
鸟类羽毛的发育涉及从毛到幼羽毛的过渡,由表观遗传机制驱动. 这项研究揭示了羽毛结构和进化中的SOX14和Wnt信号等关键分子参与者.
科学领域:
- 发展生物学 发展生物学
- 进化生物学 进化生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 羽毛的发育对于鸟类的适应至关重要,从新生羽毛过渡到飞行准备的青少年羽毛.
- 控制这种重要的羽毛过渡的表观遗传机制在很大程度上仍未被探索.
- 了解这一过程可以让我们深入了解鸟类的进化和羽毛形态发生.
研究的目的:
- 阐明基因表观机制,从毛转变为青少年羽毛.
- 确定关键的分子参与者和参与羽毛发育的信号通路.
- 研究不同鸟类物种中这种过渡的进化保护.
主要方法:
- 时间排序的基因共同表达网络构建.
- 在发育羽毛毛囊中的表观遗传学分析.
- 功能性扰动来研究羽毛发育.
主要成果:
- 细胞外矩阵重组促进了表皮-介质细胞相互作用,以促进羽毛的分支.
- 阿尔法平滑肌动蛋白 (α-SMA) 调节了用于羽毛循环的干细胞细分.
- LEF1充当Wnt信号枢纽,指导拉基斯的形成和对称性.
- 状质素和SOX14有助于加强羽毛外.
- 这种过渡在早期 () 和其他早期 (斑马) 物种中得到保护.
结论:
- 羽毛从小到年轻的过渡是由特定的表观遗传调节器和信号通路协调的.
- 这个过程在进化过程中得到了保存,这表明古代起源可能在羽毛恐龙中.
- 这些发现为了解羽毛进化和发育生物学提供了基础.
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