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Updated: Jun 26, 2025

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核酸结合蛋白 SFPQ 通过促进 histone H1 表达抑制了 EBV 的解活性

Laura A Murray-Nerger1,2,3,4, Clarisel Lozano1, Eric M Burton1,2,3,4

  • 1Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA.

Nature communications
|May 16, 2024
PubMed
概括

核蛋白SFPQ通过调节质子H1表达来维持爱斯坦-巴尔病毒 (EBV) 延迟. 破坏SFPQ会触发EBV的重新激活,从而揭示出一种保存的玛疹病毒机制.

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Eukaryotic Transcription Inhibitors

Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
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