通过皮肤进行的耳膜迷走神经刺激,可以通过中央胆固醇系统激活来增强短延迟的 afferent 抑制
Takayuki Horinouchi1,2, Tomohisa Nezu3, Kazuya Saita4
1Department of Sensorimotor Neuroscience, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
Scientific reports
|May 16, 2024
概括
持续的透皮耳道迷走神经刺激 (taVNS) 有效地增强了短延迟附带抑制 (SAI),表明胆神经系统活性增加. 这一发现突出了taVNS的重要意义.
科学领域:
- 神经科学是一个神经科学.
- 生理学 生理学 生理学
- 生物医学工程 生物医学工程
背景情况:
- 胆固醇系统在调节神经活动中起着至关重要的作用,并与各种生理过程有关.
- 短延迟附带抑制 (SAI) 作为一个可靠的间接生物标志物来评估胆固醇系统的激活.
- 通过皮肤进行耳道迷走神经刺激 (taVNS) 是一种具有潜在治疗应用的非侵入性神经调节技术.
研究的目的:
- 调查持续的通过皮肤的耳道迷走神经刺激 (taVNS) 对短延迟关联抑制 (SAI) 的影响.
- 评估taVNS作为调节胆固醇神经系统活性的一种方法.
- 探索基线SAI水平和对taVNS的反应之间的关系.
主要方法:
- 24名健康成年人参与了一项涉及间歇和连续taVNS协议的随机研究.
- 在taVNS之前,立即之后和15分钟后使用跨磁刺激 (TMS) 和中枢神经调节刺激来测量SAI.
- 连续的taVNS (25Hz,15分钟) 与间歇的taVNS和假刺激进行了比较.
主要成果:
- 与基线水平相比,连续taVNS在刺激后15分钟显著增加了SAI.
- 在基线SAI和连续taVNS后SAI变化的幅度之间发现了正相关性.
- 在taVNS之后的SAI增加在基线SAI较低的个体中更为明显.
结论:
- 15分钟的连续taVNS有效地增强了胆固醇神经系统的活动,正如增加的SAI所表明的那样.
- taVNS显示出作为一种临床工具的潜力,用于管理与胆功能障碍相关的疾病.
- 基线SAI的个体差异可以预测taVNS干预的反应.
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