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预先存在的抑郁和焦虑与Omicron变种感染的关联
Huazhen Yang1,2, Lei Yang3, Wenwen Chen1,2
1Department of Anesthesiology and West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China.
Molecular psychiatry
|May 16, 2024
概括
以前存在的抑郁症和焦虑症并没有增加Omicron感染风险,但与更严重的结局有关. 这凸显了在Omicron流行期间对风险人群进行监测和早期干预的必要性.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 精神病学是一个精神病学.
背景情况:
- 之前的研究将先前存在的精神疾病与在最初的流行病浪潮期间增加的COVID-19易感性联系起来.
- 关于前存在的抑郁症或焦虑症与在Omicron变种流行期间的COVID-19易感性之间的联系的证据有限.
- 了解这些关联对于正在进行的病毒演变期间的公共卫生策略至关重要.
研究的目的:
- 调查先前存在的抑郁或焦虑与Omicron感染风险之间的联系.
- 为了检查先前存在的抑郁或焦虑和Omicron感染的严重程度之间的关联.
- 通过中国和英国生物库的潜在队列来验证研究结果.
主要方法:
- 分析了中国的两个潜在队列 (N=10,802) 和英国生物库的数据.
- 患有抑郁症/焦虑症史或症状的参与者与未暴露的个人进行了比较.
- 通过COVID-19多基因风险评分 (PRS) 采用多变量逻辑回归和分层.
主要成果:
- 在先前存在的抑郁症/焦虑症和Omicron感染的整体风险之间没有发现显著的关联.
- 在先前存在的抑郁症/焦虑症和严重的Omicron感染 (需要医疗干预或严重症状) 之间观察到积极的关联.
- 在不同的队列和分层分析中获得了可比的估计值,包括症状模式分析.
结论:
- 以前存在的抑郁症和焦虑症与感染Omicron感染的风险增加无关.
- 以前患有抑郁症和焦虑症的个人面临患有严重的Omicron感染的风险较高.
- 在Omicron流行期间,建议对这种高风险人群进行持续监测和早期干预策略.
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