维生素D缺乏的患病率和模式及其在南印度队列中的认知功能中的作用
Aishwarya Ghosh1, Monisha S1, Albert Stezin Sunny1
1Centre for Brain Research, Indian Institute of Science Campus, CV Raman Avenue, Bangalore, 560012, India.
Scientific reports
|May 16, 2024
概括
维生素D缺乏症在45岁以上的成年人中很常见,并且与较低的口语流性有关. 这种缺乏也会影响脂质代谢,强调维生素D水平与认知健康之间的联系.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 老年学是一门学科.
背景情况:
- 维生素D (VitD) 在和平衡中起着至关重要的作用,并具有神经保护性质.
- 维生素D缺乏与成年人的认知障碍和痴呆症风险越来越相关.
- 了解VitD水平与老年人群的认知功能之间的联系至关重要.
研究的目的:
- 研究25-基维生素D[25(OH) D]水平与45岁及以上认知健康成年人的认知功能之间的关系.
- 探索VitD状态,认知表现和其他健康指标 (如失脂症) 之间的潜在关联.
主要方法:
- 评估了一组982名认知健康的成年人 (≥45岁) 来自CBR-Tata长度老化研究 (TLSA).
- 使用阿登布鲁克的认知检查-III (ACE-III) 和印度语精神状态检查 (HMSE) 评估认知功能.
- 血清25(OH) D水平分为不足 (<20 ng/ml),不足 (20-29 ng/ml) 和正常 (≥30 ng/ml);统计分析包括克鲁斯卡尔-瓦利斯H,奇方位和GLM.
主要成果:
- 在参与者中观察到VitD缺乏 (58%) 和不足 (23%) 的高患病率.
- 在调整年龄,教育程度,性别和脂质障碍症后,VitD缺乏与ACE-III口语流度的较低得分显著相关.
- 在VitD缺乏和脂质失调之间发现了强烈的相关性,91.2%的缺乏个体也患有脂质失调.
结论:
- 维生素D水平较低与45岁及以上成年人口语流性受损有关.
- 维生素D缺乏症和脂质失调症的显著同时发生表明维生素D对脂质代谢的潜在影响.
- 需要进一步的研究来探索VitD缺乏,认知领域和代谢健康之间的多方面的关系.
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