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Updated: Aug 7, 2026

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在慢性淋巴细胞白血病中对TP53突变分析的ERIC建议-2024年更新

Jitka Malcikova1,2, Sarka Pavlova1,2, Panagiotis Baliakas3

  • 1Department of Internal Medicine, Hematology and Oncology, and Institute of Medical Genetics and Genomics, University Hospital Brno and Medical Faculty, Masaryk University, Brno, Czech Republic.

Leukemia
|May 16, 2024
PubMed
概括

在慢性淋巴细胞白血病 (CLL) 中对TP53分析的最新指南强调在检测TP53突变时,对特定变异的等位基因频率切断值进行彻底的方法验证. 这些建议旨在改善患者管理和临床试验分层.

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相关概念视频

Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...