帕金森病与焦虑:临床特征及其与氧化应激,炎症和病理蛋白质的相关性
Tenghong Lian1, Weijiao Zhang2, Danning Li2
1Center for Cognitive Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
BMC geriatrics
|May 16, 2024
概括
在帕金森病 (PD) 中,焦虑是常见的,焦虑患者表现出更糟糕的运动和非运动症状. 增加的基 (·OH) 和瘤亡因子-α (TNF-α),以及减少的氧化 (NO) 与PD中的焦虑有关.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 临床医学 临床医学
背景情况:
- 帕金森病 (PD) 是一种神经退行性疾病.
- 焦虑是PD患者常见的并发症.
- 了解PD中焦虑的生物学基础对于改善患者护理至关重要.
研究的目的:
- 研究患有焦虑症的PD患者 (PD-A) 和没有焦虑症的PD患者 (PD-NA) 之间临床特征的差异.
- 为了比较PD-A和PD-NA组之间的氧化应激指标,炎症因素和病理蛋白质的血清水平.
- 在两组中分析临床症状与这些生物标志物之间的相关性.
主要方法:
- 121名PD患者使用汉密尔顿焦虑量表 (HAMA-14) 进行评估.
- 患者被分为PD-A (HAMA-14分数≥7) 和PD-NA组.
- 血清生物标志物,包括自由基 (基[·OH],氧化[NO]),炎症因子 (瘤缩因子-α[TNF-α]) 和病理蛋白质,使用色度和ELISA方法进行测量.
主要成果:
- 在PD中,焦虑的患病率为62.81%.
- 与PD-NA患者相比,PD-A患者的运动功能,非运动症状 (疲劳,睡眠行为障碍,不安腿综合征,自主功能障碍) 和日常生活活动明显恶化.
- 在PD-A组中观察到血清OH和TNF-α的升高以及NO水平的降低. ·OH,NO和TNF-α被确定为PD-A的危险因素.
结论:
- 焦虑在帕金森病中非常普遍,并且与更严重的临床表现有关.
- 增加的OH和TNF-α,以及降低的NO血清水平与PD患者的焦虑严重程度有关.
- 这些发现突出了焦虑,氧化应激,炎症和PD潜在的认知衰退之间的相互作用,为疾病机制提供了洞察力.
相关概念视频
Parkinson's Disease: Overview
533
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
533
Parkinson's Disease: Treatment
263
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
263
Neural Regulation
39.4K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.4K
Alzheimer's Disease: Overview
467
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
467
Psychoneuroimmunology: Cardiovascular Disease
30
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
30
Anxiety: Overview
265
Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
265


