状多重症综合征:定义流行病学和预测失生症的风险
Natalie R Dierick1,2, Brian D Nicholson3, Thomas R Fanshawe3
1School of Clinical Medicine, University of New South Wales, Rural Clinical Campus, Port Macquarie, Kensington, NSW, Australia. natalie.dierick95@gmail.com.
BMC gastroenterology
|May 16, 2024
概括
状多综合征 (SPS) 比以前认为的更为常见. 临床和内镜因素可以预测SPS患者的发育不良风险,有助于早期检测瘤变化.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 状多重体综合征 (SPS) 是一种常见的结直肠多重体,具有瘤潜力.
- 在SPS中,自然史,遗传学和失生症/新生症风险仍然不完全理解.
- 对SPS患者的管理来说,精确预测发育不良症至关重要.
研究的目的:
- 定义"有丝多重症综合征"的流行病学.
- 在SPS患者中识别SPS病变 (SSLs) 形和瘤的预测因子.
- 开发和评估SPS中异位性SSL的临床预测模型.
主要方法:
- 对247名被诊断患有SPS的患者进行了回顾性队列研究.
- 2015年1月至2021年9月期间从结肠镜检查中收集的数据.
- 多变量逻辑回归模型 (临床和内镜) 用于预测失塑性SSL.
主要成果:
- 在8401次结肠镜检查中,SPS患病率为2.94%.
- 失塑性SSL的预测因素包括年龄较大,结直肠癌的个人病史以及SSL大小/数量.
- 临床和内镜模型实现了接受器操作曲线下的面积 (AUC) 为0.75.
结论:
- 状多重症综合征比以前报告的更为普遍.
- 鉴定的临床和内镜变量显示可接受的准确性来预测发育不良的风险.
- 需要在多样化的群体中进行进一步的研究,以获得可概括性和改进模型性能.
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