相关实验视频
Updated: Jun 26, 2025

05:37
An R-Based Landscape Validation of a Competing Risk Model
Published on: September 16, 2022
2.0K
多基因预测模型的概括性:在测试数据上,R2是如何定义的?
Christian Staerk1,2, Hannah Klinkhammer3,4, Tobias Wistuba3
1Department of Medical Biometry, Informatics and Epidemiology, Medical Faculty, University of Bonn, Bonn, Germany. christian.staerk@uni-bonn.de.
BMC medical genomics
|May 16, 2024
概括
测试数据上的R平方的定义显著影响了多基因风险评分 (PRS) 的概括性. 选择正确的R平方定义对于准确的PRS解释和在个性化医学中的应用至关重要.
科学领域:
- 遗传学 是一个遗传学.
- 生物统计学 生物统计学
- 个性化医疗是个性化的医疗.
背景情况:
- 多基因风险评分 (PRS) 对个性化医学至关重要,可以量化遗传倾向.
- 一个关键的挑战是确保PRS模型在各种祖先中具有普遍性.
- R-平方通常用于评估测试数据上的PRS预测准确性.
研究的目的:
- 为了比较三个R平方定义来评估PRS对测试数据的概括性.
- 分析不同R平方定义对跨祖先的PRS模型性能的影响.
主要方法:
- 利用英国生物库的基因型数据进行分析.
- 使用欧洲祖先培训数据,为身高,BMI和脂蛋白A衍生了多基因模型.
- 在不同的测试群体上评估模型,比较三个R平方定义.
主要成果:
- 选择R平方定义显著改变了PRS的概括性结果.
- 基于相关性的R平方测量了歧视性表现 (0-1范围).
- 基于MSPE的R-squared评估了歧视和校准,可能会对错误校准的预测产生负值.
结论:
- 明确说明使用的R平方定义对于报告PRS概括性至关重要.
- 了解R平方定义有助于准确解释PRS在不同人群中的表现.
- 对于在不同人群中进行精确校准的PRS模型,需要进一步的研究.
相关概念视频
Variation
6.8K
An important characteristic of any set of data is the variation in the data. In some data sets, the data values are concentrated closely near the mean; in other data sets, the data values are more widely spread out from the mean. The most common measure of variation, or spread, is the standard deviation, which is the square root of variance.
When independent and dependent variables are plotted on a scatter plot, the slope of a line is a value that describes the rate of change between the two...
When independent and dependent variables are plotted on a scatter plot, the slope of a line is a value that describes the rate of change between the two...
6.8K
Calculating and Interpreting the Linear Correlation Coefficient
5.9K
The correlation coefficient, r, developed by Karl Pearson in the early 1900s, is numerical and provides a measure of strength and direction of the linear association between the independent variable, x, and the dependent variable, y. Hence, it is also known as the Pearson product-moment correlation coefficient. It can be calculated using the following equation:
5.9K
Multiple Regression
3.0K
Multiple regression assesses a linear relationship between one response or dependent variable and two or more independent variables. It has many practical applications.
Farmers can use multiple regression to determine the crop yield based on more than one factor, such as water availability, fertilizer, soil properties, etc. Here, the crop yield is the response or dependent variable as it depends on the other independent variables. The analysis requires the construction of a scatter plot...
Farmers can use multiple regression to determine the crop yield based on more than one factor, such as water availability, fertilizer, soil properties, etc. Here, the crop yield is the response or dependent variable as it depends on the other independent variables. The analysis requires the construction of a scatter plot...
3.0K
Calibration Curves: Correlation Coefficient
1.6K
In a linear calibration curve, there is a value called the calibration coefficient, denoted by 'r,' which measures the strength and the direction of association between two variables. The correlation coefficient value ranges from −1 to +1. A value of +1 indicates a perfect positive linear correlation, −1 denotes a perfect negative correlation, and 0 implies no correlation between the two variables. A positive correlation value establishes that as one variable increases, the...
1.6K
Sensitivity, Specificity, and Predicted Value
291
In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...
Sensitivity is the...
291
Coefficient of Correlation
6.1K
The correlation coefficient, r, developed by Karl Pearson in the early 1900s, is numerical and provides a measure of strength and direction of the linear association between the independent variable x and the dependent variable y.
If you suspect a linear relationship between x and y, then r can measure how strong the linear relationship is.
What the VALUE of r tells us:
The value of r is always between –1 and +1: –1 ≤ r ≤ 1.
The size of the correlation r indicates the...
If you suspect a linear relationship between x and y, then r can measure how strong the linear relationship is.
What the VALUE of r tells us:
The value of r is always between –1 and +1: –1 ≤ r ≤ 1.
The size of the correlation r indicates the...
6.1K

