支气管切除症与达到常见变量免疫缺陷患者目标谷免疫球蛋白G水平的时间之间的关系
Tugba Onalan1, Fatih Colkesen1, Mehmet Kilinc2
1From the Division of Clinical Immunology and Allergy, Department of Internal Medicine, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey, and.
常见变性免疫缺陷 (CVID) 患者的支气管切除延长了达到目标免疫球蛋白G (IgG) 水平的时间,影响了感染频率. 这强调了在CVID管理中需要量身定制的治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 常见变性免疫缺陷 (CVID) 治疗的目的是维持免疫球蛋白G (IgG) 水平.
- 个体IgG的最低水平不同,尽管免疫球蛋白替代疗法 (IGRT) 剂量和体重指数 (BMI) 一致.
- 支气管切除是影响IgG救援途径和治疗疗效的关键因素.
研究的目的:
- 为了比较CVID患者的低位IgG水平,有和没有支气管切除症,接受相同的IGRT剂量.
- 为了确定IgG水平和感染频率之间的关联,在CVID患者有支气管切除症.
- 评估需要达到目标IgG水平与支气管切除症存在相关的时间.
主要方法:
- 在61名CVID患者 (21名支气管切除症患者) 的回顾性队列研究中.
- 分析了人口统计数据,基线免疫球蛋白水平,两年来IgG水平的平均低谷值,以及感染频率.
- 评估达到目标最低IgG水平 (700 mg/dL) 和IgG疗效水平的时间.
主要成果:
- 支气管切除症患者的IgG和疗效水平较低 (P < 0.001和P = 0.016).
- 在患有支气管切除症的患者中,需要显著更长的时间才能达到目标IgG水平.
- 达到目标IgG水平的时间与感染频率有显著的关联.
结论:
- 支气管切除与在CVID患者中达到目标IgG水平的持续时间显著相关.
- 这些发现强调了在CVID管理中考虑支气管切除的临床重要性.
- 在IgG水平和治疗反应的差异需要个性化的IGRT策略.
更多相关视频
10:26P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives
Published on: June 15, 2020
06:49Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians
Published on: March 14, 2014
相关概念视频
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Cystic Fibrosis: Management
Sinus disease and chronic...
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
COPD: Management Using Bronchodilators and Corticosteroids
