儿童注意力缺陷多动障碍和自闭症的注意力预警和注意力听觉事件相关的潜力
Ulrich Schall1,2,3, Ross Fulham1,3, Max Günther1,4
1Centre for Brain and Mental Health Research, Mater Hospital, The University of Newcastle, New South Wales, Australia.
Clinical EEG and neuroscience
|May 17, 2024
概括
自闭症和ADHD的听觉处理差异可以使用事件相关潜力 (ERP) 来识别. 不匹配负面性 (MMN) 和P3b振幅显示出潜在的自闭症和ADHD的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 临床听力学 临床听力学
背景情况:
- 听力处理异常与自闭症和注意力缺陷多动症障碍 (ADHD) 有关.
- 这些神经发育状况在儿童中经常同时发生,使干预策略复杂化.
- 与事件相关的潜力 (ERP) 正在成为自闭症和ADHD的潜在客观生物标志物.
研究的目的:
- 调查不匹配负面性 (MMN) 和P3b事件相关潜力 (ERP) 作为自闭症和/或多动症儿童的潜在生物标志物.
- 检查与年龄相关的MMN和P3b振幅在神经类型儿童和患有自闭症,多动症或并发症的儿童中的变化.
- 为了区分与自闭症和ADHD相关的听觉处理模式.
主要方法:
- 一个被动的倾听任务被用来引起不匹配负面性 (MMN).
- 一个活跃的审计去/不去歧视任务被用来测量P3b.
- 电脑电图 (EEG) 记录来自103名年龄在4~17岁的儿童,分为多动症,自闭症,多动症自闭症和神经类型 (NT) 组.
主要成果:
- 在所有参与者中,MMN和P3b的幅度通常随着年龄的增长而增加.
- 患有ADHD的老年儿童显示P3b振幅降低,而较年轻的自闭症儿童与NT同龄人相比显示MMN振幅降低.
- 患有自闭症和ADHD并发症的儿童没有遵循这些特定模式,与NT儿童更相似.
结论:
- 自闭症儿童的MMN振幅降低和ADHD儿童的P3b振幅降低表明它们作为特定疾病生物标志物的潜力.
- 与事件相关的潜能 (ERP),如MMN和P3b,可能为区分自闭症和ADHD提供客观的措施.
- 为了临床应用,需要进一步的研究,包括协议优化,标准化和纵向研究.
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