高龄对类风湿性关节炎的影响:一个多中心超声波队列研究
Chieko Kawahara1, Shoichi Fukui1, Tohru Michitsuji1,2
1Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Modern rheumatology
|May 17, 2024
概括
老年类类风湿性关节炎 (RA) 患者表现出明显的临床特征. 治疗作用机制 (MOA) 在这个年龄组中没有显著影响临床或超声结果.
科学领域:
- 类风湿病学 类风湿病学
- 临床免疫学临床免疫学
- 老年医学 老年医学
背景情况:
- 类风湿性关节炎 (RA) 管理已经发展成为有针对性的疗法.
- 了解RA中与年龄相关的差异对于个性化治疗至关重要.
研究的目的:
- 评估年龄如何影响生物或向合成疾病修饰性抗风湿药物 (b/tsDMARD) -先前的RA患者的临床特征和治疗结果.
- 为了比较老年 (≥60岁) 和年轻 (<60岁) 的RA患者在基线特征和12个月治疗反应方面.
主要方法:
- 从多中心超声波前性观察队伍中对234名日本b/tsDMARD-naïveRA患者的分析.
- 临床和超声数据在基线和12个月之间的年龄组之间的比较 (≥60比<60岁).
主要成果:
- 60岁以上的RA组显示出更高的基线炎症标志物和超声波得分,特别是在手腕关节.
- 年龄与基线超声波得分有积极的相关性,但在多重回归分析中并不是显著因素.
- 作用机制 (MOA) 在老年RA患者12个月后没有显著影响临床疾病活动指数.
结论:
- 在RA患者中,晚年与独特的临床和成像特征有关.
- b/tsDMARDs的作用机制似乎没有影响老年RA患者的临床或超声结果.
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