由肠道病毒引起的中枢神经系统感染患者的生物标志物和基因型
Karolina Alsén1,2, Marianela Patzi Churqui1,3, Helene Norder1,3
1Institute of Biomedicine, Department of Infectious Diseases, University of Gothenburg, Gothenburg, Sweden.
Infectious diseases (London, England)
|May 17, 2024
概括
肠道病毒脑膜炎没有脑细胞损伤的迹象,但已经降低了粉样蛋白-β和蛋白的水平. 一些患者在感染后经历认知障碍,尽管其与生物标志物的联系尚不清楚.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 生物化学 生物化学
背景情况:
- 肠道病毒 (EV) 是无菌性脑膜炎的常见原因,这是一个严重的中枢神经系统 (CNS) 感染.
- 肠道病毒对大脑的确切影响以及EV类型之间的潜在差异尚未得到充分理解.
- 脑脊液 (CSF) 生物标志物是评估中枢神经系统感染中脑损伤的宝贵工具.
研究的目的:
- 通过使用CSF生物标志物,研究肠道病毒脑膜炎患者的潜在神经元和天体细胞损伤.
- 探索特定的肠道病毒类型和生物标志物水平之间的相关性.
- 评估急性肠道病毒脑膜炎后认知障碍的发生.
主要方法:
- 一项回顾性研究分析了38名患有急性神经症状和确诊肠道病毒感染的患者的CSF样本.
- 测量了包括神经丝光 (NFL),质纤维酸蛋白 (GFAP),S-100B,粉样β (Aβ) 40和Aβ42,总tau (T-tau) 和化tau (P-tau) 在内的关键生物标志物.
- 结果与对照组 (n=19) 相比,通过测序对17个EV样本进行了类型化.
主要成果:
- 与对照组相比,在患者中没有观察到GFAP或NFL水平的显著升高,这表明没有明显的神经元或天体细胞损伤.
- 在患有EV脑膜炎的患者中发现Aβ42,Aβ40,T-tau,P-tau和S-100B水平显著降低.
- 埃科病毒30和Coxsackievirus B5是最常见的EV类型,但生物标志物水平没有显著差异与特定的EV类型相关.
结论:
- 该研究没有发现基于GFAP和NFL水平的肠道病毒脑膜炎中神经元或天体细胞损伤的证据.
- 观察到粉样β和蛋白度下降,尽管目前尚不清楚它们的临床意义.
- 虽然在一些患者中报告了感染后的认知障碍,但有限的样本规模阻止了对特定生物标志物水平或EV类型的关联得出结论.
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