布罗利祖马布诱导的胰腺炎:用一粒盐服用
Prachi C Gajjar1, Parth Parmar1, Hetvi Gajjar2
1Internal Medicine, Western Reserve Health Education, Warren, USA.
Cureus
|May 17, 2024
概括
布罗利祖马布 (Keytruda) 可能导致罕见的副作用,如急性胰腺炎. 这一案例突出了接受Keytruda治疗前列腺癌的患者潜在的不良事件.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 布罗利祖马布 (Keytruda) 是一种针对PD-1/PD-L1通路的免疫治疗药物.
- 免疫相关不良事件 (irAEs) 是PD-1抑制剂的已知并发症.
- 多系统性毒性可能由于增强的免疫反应而发生.
研究的目的:
- 报告一种罕见的急性胰腺炎病例.
- 描述与 pembrolizumab 治疗相关的不良事件.
- 为了解Keytruda在前列腺癌中的安全概况做出贡献.
主要方法:
- 一个64岁的男性患者的病例报告.
- 对临床病史和治疗过程的审查.
- 排除胰腺炎的其他潜在原因.
主要成果:
- 患者在接受了六个月的布罗利祖马布治疗后出现了急性胰腺炎.
- 凯特鲁达的八个周期被用于割抗性转移性前列腺癌.
- 排除了胰腺炎的其他病因.
结论:
- 急性胰腺炎是pembrolizumab的一个潜在的,尽管很少见的不良影响.
- 临床医生应考虑在Keytruda患者中出现相关症状的胰腺炎.
- 进一步调查iRAE机制是有必要的.
相关概念视频
01:24Chronic Pancreatitis I: Introduction
87
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
87
01:30Acute Pancreatitis II: Clinical Manifestations and Management
122
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
122
01:27Acute Pancreatitis I: Introduction
355
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
355
01:29Chronic Pancreatitis II: Collaborative Care
85
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
85
01:23Dipeptidyl Peptidase 4 Inhibitors
181
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
181