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基于生理学的药理动力学建模,以预测不同CYP2D6表型中的可代因的药理动力学

Yujie Yang1, Xiqian Zhang1, Yirong Wang1

  • 1Department of Pharmacy, The Third People's Hospital of Chengdu, College of Medicine, Southwest Jiaotong University, Chengdu, China.

Frontiers in pharmacology
|May 17, 2024
PubMed
概括

基于生理学的药理动力学模型揭示了CYP2D6遗传变异如何影响代因和吗啡水平. 由于减少了吗啡暴露,可代因在低代谢者的疼痛缓解效果较低.

关键词:
在CYP2D6中.代代因是指一种可代因.遗传多形态主义是一种遗传多形态主义.药物动力学 药物动力学基于生理学的药物动力学.

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