风险因素与瘤升级相关的黑色素瘤治疗莫斯微图外科手术与黑色素细胞免疫组织化学治疗
Thomas Trischman1, Anagha Bangalore Kumar1, Eucabeth M Asamoah1
1Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
JAAD international
|May 17, 2024
概括
使用黑色素细胞免疫组织化学 (MMS-I) 的莫斯微图外科手术具有较低的黑色素瘤升级率. 缺少切除意图和现场诊断等因素增加了升级风险.
科学领域:
- 皮肤病学 皮肤病学
- 手术瘤学手术瘤学
- 病理学 病理学 病理学
背景情况:
- 使用黑色素细胞免疫组织化学 (MMS-I) 的莫斯微图手术越来越多地用于黑色素瘤治疗.
- 关于使用MMS-I治疗黑色素瘤的升级频率和风险因素的数据有限.
研究的目的:
- 为了确定使用MMS-I治疗的所有阶段皮肤黑色素瘤的升级频率.
- 为了确定这些病例中与瘤升级相关的因素.
主要方法:
- 追溯,单中心病例系列,包括962例黑色素瘤病例,这些病例接受了MMS-I治疗 (2008-2018).
- 在升级和非升级瘤之间比较患者和瘤特征.
主要成果:
- 总体上升阶段的比率为4.6% (5.6%在现场,2.5%侵入性).
- 升级阶段的风险因素包括缺少切除意图,非lentigo恶性亚型,女性性别和初始现场诊断.
结论:
- 用MMS-I治疗的皮肤黑色素瘤具有较低的升级率.
- 升级与缺少切除意图,女性性别和局部瘤有关.
相关概念视频
01:30Skin Cancer
4.1K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.1K
02:17The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K