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尿动血管酶转化酶2及其在患有慢性病的猫群中的活性
Tzu-Chien Kuo1, Wei-Li Hsu2, Vin-Cent Wu3
1Institute of Veterinary Clinical Science, School of Veterinary Medicine, College of Bio-Resources and Agriculture, National Taiwan University, Taipei, Taiwan.
Frontiers in veterinary science
|May 17, 2024
概括
尿动血管酶转化酶2 (uACE2) 度随着猫类慢性病 (CKD) 的进展而增加,而其活性则下降. 然而,uace2在本研究中没有预测CKD的进展.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物化学 生物化学
背景情况:
- ангиотензин转化酶2 (ACE2) 在氨酸- ангиотензин- 阿尔多斯特系统中至关重要,并表现出保护作用.
- 尿路ACE2 (uACE2) 在人类和实验模型中表明损伤.
- 目前尚不清楚uace2在猫病中的作用.
研究的目的:
- 将患有不同阶段慢性病 (CKD) 的猫的UACE2度和活动与健康对照进行比较.
- 研究UACE2水平,临床病理学数据和CKD之间的相关性.
- 评估UACE2对CKD进展的预测能力.
主要方法:
- 一个追溯的,病例控制研究设计.
- 使用ELISA套件量化UACE2度.
- 通过度测试工具测量UACE2活性.
- 计算UACE2度与肌素比率 (UACCRs).
主要成果:
- 与对照组相比,早期和晚期猫类CKD猫的UACCR显著升高 (p < 0.001).
- 尿路ACE2活性 (UAA) 在CKD猫与健康猫相比显著较低 (p < 0.001).
- UACCR与BUN正相关 (p < 0.001),UAA与血肌素负相关 (p < 0.001).UACCR与BUN正相关 (p < 0.001),UAA与血肌素负相关 (p < 0.001).
结论:
- 猫的uACE2度和活性随着功能下降而变化,特别是在晚期的CKD中.
- 虽然UACE2水平与损伤标志物相关,但它们无法预测该队列中的CKD进展.
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