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相关概念视频

Higher Mental Functions of the Brain: Language01:10

Higher Mental Functions of the Brain: Language

796
Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
796

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相关实验视频

Updated: Jun 26, 2025

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
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一个来自质瘤的流利言语大脑网络.

Cechen Sun1, Jie Zhang2,3,4,5,6, Linghao Bu2,3,4,5,6

  • 1Department of Biostatistics, School of Public Health & National Clinical Research Centre for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.

Brain communications
|May 17, 2024
PubMed
概括

这项研究绘制了大脑网络,支持低度质瘤患者的言语流性. 对特定大脑区域和白质路径的损伤显著影响语言流性,揭示了需要进行手术考虑的关键领域.

关键词:
语言网络语言网络低度结质瘤 低度结质瘤语言流 语言流

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科学领域:

  • 神经科学是一个神经科学.
  • 神经外科 神经外科
  • 语言病理学 语音病理学

背景情况:

  • 语音流的基础神经网络仍然不完全理解,特别是在大型,均的患者队列中.
  • 以前的研究没有使用多式成像全面调查大脑的语言流利网络.
  • 了解这种网络对于在神经外科干预期间保持语言功能至关重要.

研究的目的:

  • 探索和绘制大脑网络的地图,这对语言流性至关重要.
  • 识别与言语流性缺陷相关的特定大脑区域和白质道.
  • 调查支持流利言语的连接模式.

主要方法:

  • 分析了来自115名低度质瘤患者的多式成像数据.
  • 基于voxel的病变症状映射 (VLSM) 的应用,以将脑损伤与流性相关联.
  • 使用直接皮质刺激和连接性-行为分析,对关键区域进行手术内验证.

主要成果:

  • 在VLSM中,中前环,前中环,下前环和内环的损伤与减少的言语流性显著相关.
  • 白质道的损伤,包括皮质脊髓,内部囊,弧形,无状,以及与语音缺陷相关的正面位通道.
  • 连接性分析揭示了特定的神经连接和语音流性之间的显著相关性,突出了域特定区域和域一般区域之间的相互作用.

结论:

  • 该研究成功地绘制了支持语言流性的大脑网络,涉及关键的灰质区域和白质区域.
  • 研究结果表明,大脑相互连接的区域,包括额头部,部和部区域,在保持流利的言语方面发挥着集体作用.
  • 这个详细的网络地图为神经外科医生提供了一个重要的资源,可以在质瘤手术期间尽量减少语言功能障碍.