关于血管新生素在恶性瘤中的结构,功能和使用的研究进展
Mingwen Mao1,2, Weina Chen3, Dong Ye2
1Department of Otorhinolaryngology-Head and Neck Surgery, Ningbo No.6 Hospital Affiliated Medical School of Ningbo University, 315040, Ningbo, Zhejiang, China.
Heliyon
|May 17, 2024
概括
血管新生素 (ANG) 是一种与各种癌症相关的核糖酶. 本综述探讨了ANG在癌症发展和进展中的作用,以及其作为诊断和治疗生物标志物的潜力.
科学领域:
- 生物化学 生物化学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 血管新生素 (ANG),也称为RNase5,是脊椎动物中发现的一种分泌的核糖酶.
- ANG失调与乳腺癌,鼻癌和肺癌有关.
- ANG影响癌细胞的可塑性和新血管化.
研究的目的:
- 审查当前对血管新生素在癌症中的作用的理解.
- 总结 ANG 在癌症发展和进展中的临床应用.
主要方法:
- 对血管新生素和癌症研究的文献综述.
- 分析ANG在新血管化和癌细胞可塑性中的功能.
- 评估ANG作为潜在的癌症生物标志物.
主要成果:
- ANG通过激活内皮细胞来诱导新血管.
- ANG调节癌细胞的可塑性,影响癌细胞的开始,进展,迁移和治疗耐药性.
- 细胞可塑性是癌症发展和复发的关键因素.
结论:
- 血管新生素 (ANG) 是癌症发展和进展的一个重要因素.
- ANG在新血管和细胞可塑性中的作用凸显了它的重要性.
- 作为癌症诊断,预后和治疗的生物标志物,ANG显示出前景.
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