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Updated: Jun 26, 2025

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一个高分辨率的结构特征和物理化学研究,研究一个类蛋白如何与蛋白MDM2结合

Marin Yokomine1, Jumpei Morimoto1, Yasuhiro Fukuda1

  • 1Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 Japan jmorimoto@chembio.t.u-tokyo.ac.jp ssando@chembio.t.u-tokyo.ac.jp.

Chemical science
|May 17, 2024
PubMed
概括

这项研究揭示了类动物如何使用类动物-蛋白质复合体的第一个晶体结构与蛋白质结合. 刚性peptoid结构通过优化热力学和运动性质来增强蛋白质结合亲和力.

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Abnormal Proliferation02:23

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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