相关实验视频

Updated: Jun 26, 2025

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Published on: January 15, 2015

作为一种药物输送机制的半孔纳米颗粒

Wei Zhang¹, Hongwei Liu², Xilong Qiu³

¹Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, No. 1 West Huan-Hu Road, Ti Yuan Bei, Hexi District, Tianjin 300060, China.

Open life sciences

|May 17, 2024

概括

半孔纳米颗粒 (MSN) 通过控制释放和减少副作用,提供先进的药物输送. 这些多功能纳米材料是开发下一代智能药物输送系统 (DDS) 的关键.

科学领域:

生物医学是生物医学.
纳米技术纳米技术
材料科学材料科学材料科学

背景情况:

智能药物输送系统 (DDS) 旨在提高治疗效率并最大限度地减少副作用.
半孔纳米粒子 (MSN) 是高度重视的药物载体,因为它们的大表面积,合适的孔径大小,和生物相容性.
在MSN上的表面基组允许简单的功能化,这对于先进的DDS应用至关重要.

研究的目的:

审查在智能药物递送系统 (DDS) 中中孔纳米颗粒 (MSN) 的应用.
为了突出纳米在MSN的开发,以控制药物释放.
讨论MSNs在提高药物溶解性,稳定性和降低毒性的潜力.

主要方法:

汇编和讨论在DDS中使用的MSN的显著例子.
通过MSNs促进的受管制和渐进的药物释放机制的分析.
探索智能混合纳米材料的探索,具有对DDSs的刺激响应特性.

主要成果:

当MSN与分子机器作为纳米膜功能化时,它可以有效地防止药物过早释放.
MSN在改善药物溶解性,稳定性和降低整体毒性方面显示出显著的潜力.
结合分子开关的混合纳米材料的开发允许对各种刺激 (光,pH,酶,氧化还原) 进行可调的反应.

结论:

半孔纳米粒子是先进的智能药物输送系统的高效载体.
用纳米和刺激响应元素对MSN的功能化使药物释放能够精确控制.
MSN代表了开发下一代治疗方法的有希望的平台,具有增强的性能和安全性.

关键词:

有控制的药物释放系统.药物缓释系统是一种缓释系统.半孔的二氧化纳米粒子.审查审查审查审查审查审查

更多相关视频

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery

Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery

Published on: April 16, 2019

相关概念视频

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...

Drug Delivery: Miscellaneous Routes

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...

Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...