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头部和部皮肤状细胞癌的转移模式和治疗选择 (综述)

Doriana Iancu^1,2, Ana Fulga^1,2, Doina Vesa^1,2

¹Department of Otorhinolaryngology, 'Sfantul Andrei' Emergency Clinical Hospital of Galati, 800578 Galati, Romania.

Molecular and clinical oncology

|May 17, 2024

概括

高危的头部和部皮肤状细胞癌 (HNcSCC) 经常转移到淋巴结. 免疫疗法是关键的治疗方法,但将其与放射疗法结合可能会改善转移性HNcSCC的结果.

科学领域:

在瘤学瘤学.
皮肤病学皮肤病学
癌症研究癌症研究

背景情况:

皮肤状细胞癌 (cSCC) 是一种常见的皮肤癌,高风险的头状细胞癌 (HNcSCC) 带来了重大挑战.
转移,主要发生在局部淋巴结中,发生在约2.5%的cSCC患者中,其模式可能因瘤部位而异.

研究的目的:

审查目前关于转移性HNcSCC途径和治疗策略的文献.
确定目前和未来的转移性HNcSCC,特别是淋巴结转移的管理方向.
强调迫切需要识别那些将受益于特定局部或全身治疗的患者.

主要方法:

对HNcSCC转移现有研究的系统文献综述.
对临床和瘤特征的分析与cSCC分期不良结果相关.
评估当前和新兴的治疗选择,包括免疫治疗和放射治疗.

主要成果:

建议在转移性HNcSCC时进行免疫疗法 (例如,塞米普利马布,潘布罗利祖马布,尼沃卢马布).
与放射疗法和免疫疗法结合治疗可能会提高治疗疗效.
在HNcSCC中淋巴结转移是一个复杂的治疗挑战,需要全面的管理.

结论:

转移性HNcSCC需要量身定制的治疗策略,重点是免疫治疗.
放射治疗和免疫治疗的组合显示出改善结果的希望.
需要进一步的研究来优化治疗,并确定受益于特定干预措施的患者子组.

关键词:

在 HNcSCCCC 中.cSCCCC 的意思是什么?转移转移转移转移

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