S1PR3抑制了人类细胞核中的炎症反应和细胞外基质降解

Zhen Tian1, Haoran Gao1, Wenjun Xia1

  • 1Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.

概括

斯芬哥辛1-酸盐受体3 (S1PR3) 通过减少炎症和亡,防止椎间盘退化. 通过TLR2/STAT3和TLR2/MAPK通路,S1PR3增强了细胞活力和细胞外基质沉积.

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