相关实验视频
Updated: Jun 26, 2025
07:11
Laser Micro-Irradiation to Study DNA Recruitment During S Phase
Published on: April 16, 2021
4.3K
非编码RNA在紫外线诱导辐射效应中的作用 (综述)
Xiaofei Liang1, Chao Zhang1, Lijuan Shen2
1Department of Laboratory Medicine, The First Hospital of Qiqihar, Qiqihar, Heilongjiang 161000, P.R. China.
Experimental and therapeutic medicine
|May 17, 2024
概括
紫外线辐射 (UVR) 通过改变非编码RNAs (ncRNAs) 影响皮肤和视力. 这些ncRNAs,包括microRNAs,在UV诱导的光损伤中发挥作用,提供潜在的诊断和治疗点.
科学领域:
- 皮肤病学和分子生物学
- 摄影生物学 摄影生物学
- 在RNA生物学,RNA生物学.
背景情况:
- 紫外线辐射 (UVR),包括UVA,UVB和UVC,会造成显著的皮肤光损伤,包括炎症,衰老和癌症,并可能损害视力.
- 非编码RNAs (ncRNAs) 在转录后调节细胞过程,并与各种生物功能有关.
- 紫外线和ncRNA表达之间的相互作用是一个新兴的研究领域,对健康和疾病有影响.
研究的目的:
- 审查和总结有关ncRNAs在紫外线辐射效应中的作用和机制的当前文献.
- 探索紫外线对ncRNAs的波长特定调节.
- 突出ncRNAs作为UV诱导疾病的生物标记物和治疗点的潜力.
主要方法:
- 对研究紫外线辐射和ncRNA相互作用的综合文献综述.
- 对 ncRNA 表达模式的分析,以应对不同的紫外线波长.
- 检查ncRNAs在UV诱导光损伤中的功能作用和调节途径.
主要成果:
- 紫外线显著影响各种ncRNAs的表达,具有潜在的波长特定调节.
- ncRNAs参与多种途径中介紫外线诱导的光损伤,表现出致病性和保护性作用.
- 上调或下调的ncRNAs作为潜在的生物标志物用于诊断和评估紫外线引起的疾病的预后.
结论:
- ncRNAs是细胞对紫外线辐射反应的关键调节者.
- 向ncRNAs为开发与紫外线相关的皮肤和视觉疾病的新型诊断和治疗策略提供了一个有希望的途径.
- 对ncRNA机制的进一步研究可以提高我们对UV诱导的光损伤的理解和管理.
更多相关视频
08:18Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells
Published on: September 5, 2017
9.8K
12:43Advanced Confocal Microscopy Techniques to Study Protein-protein Interactions and Kinetics at DNA Lesions
Published on: November 12, 2017
11.0K
相关概念视频
01:38Nucleotide Excision Repair
3.5K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
3.5K
01:35Mutations
36.7K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
36.7K
01:23Types of RNA
63.6K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
63.6K
02:39lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
01:53RNA Stability
33.5K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
33.5K
02:31Nuclear Export of mRNA
7.7K
Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
7.7K