在类风湿性关节炎中宫不稳定的危险因素:元分析
Min Wang1, Jinhua Shen2, Jianghong Tan3
1Department of Rheumatology and Immunology, Zhuzhou Hospital Affiliated to Xiangya Medical College, Central South University, Zhuzhou, Hunan, China.
Archives of medical science : AMS
|May 17, 2024
概括
男性性别,更长的疾病持续时间和长期使用葡萄糖皮质类固醇是导致类风湿性关节炎 (RA) 宫不稳定的关键风险因素. 早期查和高风险RA患者的监测可以帮助预防这种并发症.
科学领域:
- 类风湿病学 类风湿病学
- 整形外科 整形外科 整形外科
- 临床流行病学临床流行病学
背景情况:
- 宫不稳定是类风湿性关节炎 (RA) 的重要并发症.
- 识别风险因素对于早期发现和预防策略至关重要.
研究的目的:
- 系统地评估和识别与风湿性关节炎 (RA) 患者宫不稳定相关的主要危险因素.
主要方法:
- 对8项研究进行了全面的元分析.
- 搜索包括主要的数据库 (PubMed,Embase,CNKI等). 在2022年11月之前.
- 包括的研究包括1个横截面,5个病例控制和2个队列研究,涉及3078名RA患者.
主要成果:
- 男性性别 (OR=1.70),更长的疾病持续时间 (OR=1.72),长期使用葡萄糖皮质类固醇 (OR=2.84),先进的斯坦布罗克分期 (OR=2.30),基线残疾 (OR=24.57),外围关节破坏 (OR=2.24),斯坦布罗克阶段I-IV的残疾进展 (OR=20.08) 和之前的关节手术 (OR=1.54) 是 RA 宫不稳定的重要风险因素.
结论:
- 几种因素增加了RA患者宫不稳定的风险.
- 临床医生应密切关注男性患者,疾病持续时间较长,长期使用葡萄糖皮质类固醇,先前的关节手术,外围关节损伤以及在斯坦布洛克I-IV阶段发展残疾的患者.
- 建议对高风险的RA患者进行早期查和全面监测,以防止宫不稳定.
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