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Jacek Siewiera¹, Michał Smoleński², Natalia Jermakow¹

¹Department of Hyperbaric Medicine, Military Institute of Medicine - National Research Institute, Warsaw, Poland.

Archives of medical science : AMS

|May 17, 2024

概括

高压氧疗法增加了在患有异常突发感官神经听力损失 (ISSNHL) 的患者中循环的小细胞外囊 (sEVs). 这一发现表明,sEV可能表明对高压氧 (HBO2) 治疗的治疗反应.

科学领域:

生物医学研究的研究.
细胞外囊泡生物学细胞外囊泡生物学
高压医学是高压医学.

背景情况:

小型细胞外囊泡 (sEVs) 越来越多地被认为是它们在生理和病理过程中的作用.
高压氧气 (HBO2) 治疗,包括在压力下吸入纯氧气,用于各种疾病.
HBO2治疗对循环sEV水平的影响在很大程度上仍未被探索.

研究的目的:

为了研究HBO2治疗对特定疾病患者血清sEV水平的影响.
为了比较在接受HBO2治疗的不同患者群体中sEV水平的变化.

主要方法:

在HBO2治疗前后,从80名患者中分离和定量血清SEV.
患者组包括患有死软组织感染 (NSTI),无菌性骨髓缩 (ABN) 和异常突发感官神经听力损失 (ISSNHL) 的患者.
为了进行比较,还包括一个没有接受HBO2治疗或类固醇的对照组.

主要成果:

在HBO2治疗后的ISSNHL患者中观察到循环sEV的显著增加 (p <0.05).
与NSTI (p < 0.05) 和ABN (p < 0.01) 患者相比,HBO2治疗导致sEV水平显著升高.
这些发现突出了基于用HBO2治疗的疾病的sEV水平的差异反应.

结论:

在ISSNHL患者中SEVs的增加可能反映了炎症减少和HBO2诱导的氧化应激抑制.
在HBO2治疗期间释放的sEVs可能在调解治疗反应中发挥生物学作用.
监测sEV水平可能为HBO2治疗的治疗疗效提供见解.

关键词:

无菌性骨坏死症的发生.外基因组是外基因组的组成部分.高压氧气疗法 (hyperbaric oxygen therapy) 是一种高压氧气疗法.异形性突发感官神经性听力损失死的软组织感染.小小的细胞外囊泡.

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