老年类类风湿性关节炎患者的贫血:一个队列研究
Zhanjuan Sun1, Haiyan Shao1, Huijie Liu1
1Department of Rheumatology, The First People's Hospital of Lianyungang/The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu Province, China.
Archives of medical science : AMS
|May 17, 2024
概括
贫血影响超过60%的老年类类风湿性关节炎 (RA) 患者具有高疾病活性. 关键的风险因素包括较长的RA持续时间,高的LDL-C,高的PLR和低的白蛋白,需要对早期干预进行监测.
科学领域:
- 类风湿病学 类风湿病学
- 老年病的医生 老年病的医生
- 血液学 血液学 血液学
背景情况:
- 贫血是诊断为类风湿性关节炎 (RA) 的老年人中普遍存在的并发症.
- 高度的RA疾病活性与此种人群中贫血的风险和严重程度增加有关.
研究的目的:
- 为了调查患病率,并确定影响贫血的因素,在老年患者高RA活动.
- 提供数据驱动的见解,以优化RA患者的临床管理和护理策略.
主要方法:
- 在2021年6月至2022年12月期间,对285名老年RA患者进行了回顾性分析,这些患者的疾病活力很高.
- 包括皮尔森相关性和后勤回归在内的统计分析被用来确定贫血的危险因素.
主要成果:
- 贫血的发病率在老年RA患者中为62.46%,具有高疾病活性.
- 在 RA 持续时间,血红蛋白 (Hb),低密度脂蛋白胆固醇 (LDL-C),血小板/淋巴细胞比率 (PLR) 和贫血和非贫血组之间的白蛋白 (Alb) 中观察到显著差异 (p <0.05).
- 后勤回归确定了RA持续时间≥8年,LDL-C ≤2.8 mmol/l,PLR ≥8和Alb ≤35 g/l作为贫血的独立风险因素 (p <0.05).
结论:
- 高度RA活性的老年患者的贫血与RA持续时间,LDL-C,PLR和Alb水平显著相关.
- 密切监测这些已识别的指标对于早期检测和干预至关重要.
- 及时管理这些因素可能会改善RA患者的整体预后.
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